Bioinformatics Workshop 3

Literature Workshop

In this workshop, we will be exploring how to search for sequence information using various web sites.
Web Resources
NCBI
Visit the NCBI website at http://www.ncbi.nlm.nih.gov
You have different options for searching for sequence information by querying the sequence annotation.
ENTREZ
PUBMED
OMIM
and several other databases
They are all linked together with links into the sequence databases.
When you do a search, you have to first ask yourself these questions
What information are you looking for?
What database would have that information?
Can you restrict your search to certain fields?
Try searching for literature about human growth hormone.
What MeSH term should you be using for that molecule?
What Database should you be searching?

Often, the best way to find something is to first, do some searches, assign some limits, then view the "history" and combine some queries. You can also do this using the Preview/Index option.

PDB
What is the unique identifying code for a protein structure of Lysozyme? You will find lots of lysozymes. Just pick one.
http://www.rcsb.org

SRS at EBI
http://srs.ebi.ac.uk
Search for Human Growth Hormone using the SRS search program.
How does the SRS search program differ from the NCBI search program that you used today.